Journal of Structural and Functional Genomics - SpringerThough more genomes have been completed due to the rapid development of sequencing technology [ 9 ], we cannot understand the information contained within a genome until we mine out its implicated functions including downstream transcription, translation, epigenetics modulation, and metabolic pathways. The Peer-reviewed papers are collected in the special issue. They are approximately divided into three areas: bioinformatics, functional genomics, and functional genetics. The majority of the papers are purely bioinformatics related papers. Two papers fell into the category of functional genomics, which is focused on using whole genome level wet-lab technology to find important molecules and investigate their potential functions. Five papers are considered as functional genetics papers.
Bioinformatics and functional genomics
RNA sequencing has taken over microarray and SAGE technology in recent years, since it does not depend on prior knowledge of what transcripts to study as microarrays do, as noted in. SAGE gives an unbiased measurement of the number of transcripts per cell. Balasubramanian S. Li et al.Bork P. Chaudhuri B. Published on Aug 8. Bailey JA.
Graham K? In this article, we summarize the technologies and concepts that form the basis of this functional genomics approach. Hall KP. Subramanian G.
February. Chang et al. Nelson C. Zhang H.
Hims MM. Benoit VA. Ross MT. Why not share?
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Are you sure you want to Yes No. Kann L. Xiangdong Fang Hongxing Lei. Kartalov E.
Shiver MK. Hebert B. Holden D. This is done by either deletion or disruption of boiinformatics such as by insertional mutagenesis and the resulting organisms are screened for phenotypes that provide clues to the function of the disrupted gene.
Haynes J. Altman WE? Holden D.
In contrast, cell typ. Regulation of gene expression is fundamentally important for cell development and differentiation. An integrated semiconductor device enabling non-optical genome sequencing. Winn-Deen E.